The CII holds an annual conference to enable and enhance close cooperation and collegiality among investigative offices of participating organizations and to facilitate the exchange of information and the discussion of critical integrity issues and new developments. The conference facilitates the continuous enhancement of the investigative function and adoption of leading practices. The conference is hosted by one of its participating organizations on a rotating basis as selected by the CII Secretariat.

Conference participants are the heads of the investigative offices of participating organizations and their selected investigative staff. In recent years, the conferences have been attended by up to 150 participants from over 40 international organizations. Participating in the conference are organizations and agencies within the United Nations system, multilateral development or investment banks and funds, quasi-governmental agencies and commissions, among a variety of other international organizations.

Topics discussed at previous annual conferences cover a wide range of areas and new innovations on fraud and corruption and include: working with bilateral aid agencies and country anti-corruption bodies, fraud in aid and reconstruction programs, investigation processes, opportunities for fraud prevention, investigation case studies in some thematic areas, intelligence sharing, developments in technology, forensic IT investigations and implementing sanctions mechanisms to name but a few. Advanced hands-on training for investigators and valuable networking events are also provided as part of the conference activities.